Friday, July 23, 2010


Innovation is a difficult and different work culture. Innovators are different kinds of people who can foresee newer possibilities in arena of their fondness. New products and technologies require lots of persuasion before they can be put to use. Although every human has some part in his life where he starts thinking differently, the innovators are people who spend most of their time thinking differently. A common man is common because he has stopped innovating in thoughts and actions.

In small budget, research is often difficult. This is because research requires lots of measurement, where one requires the inputs from sophisticated equipment. Such equipments are usually costly. Yet if an innovator has his will and has created connections well enough to take the assistance of others who have access to sophisticated equipment and instrument, it is possible to start thinking to innovate even with small budget.

Innovator should build growth strategies to execute innovative research platforms for creating products and production processes that have potentials for putting in to use in a short period of time. Projects have to be identified though their own talents which are to be designed through ideas to accelerate the development of novel products that can enter into the market successfully. All developments are steered around novel ideas that make sense.

Those who have some sense about human body can think about designing drug substances that can be couriered into different parts. Using the oral route, platforms can be conceived using bio-degradable substances which are to courier drugs to the anaerobic portions of the elementary canal like the colon through oral route, using various natural substances that are rich in carbohydrate polymers or the purified polymers themselves that are not digestible by human-borne enzymes but can be degraded by microbes that are micro-aerophilic or anerobic and are abundantly available in the human colon micro flora. The rational for developing innovative projects stems from the idea that colon targeted drug delivery is most useful and effective approach to treat colonic diseases such as colon cancer, ulcerative colitis, irritable bowel syndrome, Crohn’s disease etc. This strategy possesses inherent advantages like avoidance of exposure to gastric environment and enzymes, longer transit time, better bioavailability and low proteolytic enzyme activity. A small budget project can choose a probiotics-dependent approach. The rationale for the development of a polysaccharide based delivery system for colon is the presence of large amounts of bacteria in the human colon, which secrete many enzymes that are not produced by human. The bacterial enzymes of the colon shall degrade the carrier polymer in a well defined way and release the drugs in a definite profile for localized colonic delivery or systemic absorption through colon. Hence, a designed matrix, which is for simultaneous release of drugs and microbes are expected to result in enhanced therapeutic efficacy than individual drug therapy.

It is anticipated that it would be possible to develop a couple of products in the form of matrix granules in sachets, matrix tablets and capsules, where the matrix shall be made up of carbohydrate-rich natural substances or made from polysaccharides extracted from the natural sources. Various active drugs can be entrapped into the matrix; the matrix shall also be enriched with spores of friendly microbes. Such matrix forms of formulations shall have the abilities to deliver maximum quantities of active substances in the colon only; thereby they are expected to mount maximum combat to local lesions more efficiently than substances delivered through injectable routes. Moreover, such formulations shall also manifest minimum toxicity syndrome to the recipients. Several projects of this kind can be thought about which can be easily pursued with a small budget.