Friday, July 23, 2010


Innovation is a difficult and different work culture. Innovators are different kinds of people who can foresee newer possibilities in arena of their fondness. New products and technologies require lots of persuasion before they can be put to use. Although every human has some part in his life where he starts thinking differently, the innovators are people who spend most of their time thinking differently. A common man is common because he has stopped innovating in thoughts and actions.

In small budget, research is often difficult. This is because research requires lots of measurement, where one requires the inputs from sophisticated equipment. Such equipments are usually costly. Yet if an innovator has his will and has created connections well enough to take the assistance of others who have access to sophisticated equipment and instrument, it is possible to start thinking to innovate even with small budget.

Innovator should build growth strategies to execute innovative research platforms for creating products and production processes that have potentials for putting in to use in a short period of time. Projects have to be identified though their own talents which are to be designed through ideas to accelerate the development of novel products that can enter into the market successfully. All developments are steered around novel ideas that make sense.

Those who have some sense about human body can think about designing drug substances that can be couriered into different parts. Using the oral route, platforms can be conceived using bio-degradable substances which are to courier drugs to the anaerobic portions of the elementary canal like the colon through oral route, using various natural substances that are rich in carbohydrate polymers or the purified polymers themselves that are not digestible by human-borne enzymes but can be degraded by microbes that are micro-aerophilic or anerobic and are abundantly available in the human colon micro flora. The rational for developing innovative projects stems from the idea that colon targeted drug delivery is most useful and effective approach to treat colonic diseases such as colon cancer, ulcerative colitis, irritable bowel syndrome, Crohn’s disease etc. This strategy possesses inherent advantages like avoidance of exposure to gastric environment and enzymes, longer transit time, better bioavailability and low proteolytic enzyme activity. A small budget project can choose a probiotics-dependent approach. The rationale for the development of a polysaccharide based delivery system for colon is the presence of large amounts of bacteria in the human colon, which secrete many enzymes that are not produced by human. The bacterial enzymes of the colon shall degrade the carrier polymer in a well defined way and release the drugs in a definite profile for localized colonic delivery or systemic absorption through colon. Hence, a designed matrix, which is for simultaneous release of drugs and microbes are expected to result in enhanced therapeutic efficacy than individual drug therapy.

It is anticipated that it would be possible to develop a couple of products in the form of matrix granules in sachets, matrix tablets and capsules, where the matrix shall be made up of carbohydrate-rich natural substances or made from polysaccharides extracted from the natural sources. Various active drugs can be entrapped into the matrix; the matrix shall also be enriched with spores of friendly microbes. Such matrix forms of formulations shall have the abilities to deliver maximum quantities of active substances in the colon only; thereby they are expected to mount maximum combat to local lesions more efficiently than substances delivered through injectable routes. Moreover, such formulations shall also manifest minimum toxicity syndrome to the recipients. Several projects of this kind can be thought about which can be easily pursued with a small budget.


  1. “Innovators are different kinds of people who can foresee newer possibilities in arena of their fondness.”
    - Dr. P.K Ghosh

    “Every human has some part in his life where he starts thinking differently, the innovators are people who spend most of their time thinking differently. A common man is common because he has stopped innovating in thoughts and actions”
    - Dr. P.K Ghosh

    I must say some very “innovative” thoughts expressed by sir, in the above lines..
    It feels immense pleasure to be the part of this talk.

    I also wanted to share myself with everyone in this community.

    Innovation is using new ideas or applying thinking in fundamentally different ways that result in significant change.

    We are naturally creative and as we grow up we learn to be uncreative, because we starts following the already developed way of doing the work and we stopped thinking different way of doing, as it requires efforts of thinking and also we scared of failure in our efforts of thinking. Feeling of failure in our efforts is the main barrier of our innovative ideas, which we have to cross to achieve success in our innovation.

    Innovation is an act of turning new and imaginative ideas into reality. Creativity involves two processes: thinking, then producing. Innovation is the production or implementation of an idea. If we have ideas, but don't act on them, we are imaginative but not creative.

    So, to make a “new thing” we have to be imaginative and at the same time we should use our energy to make our imagination “a reality” which every body can see..and use…!!

  2. Respected sir...all of your blogs are very inspiring and knowledgeable....which motivates young minds of the country.
    But they are only restricted to science persons only..I think you should also write blogs for common people of the country...(like "The art of living a good life" "How to achieve success in the competitive world" "how to cope up with the adverse conditions in life" )with your great experiences of that a common person can also feels free to share himself in your blog site.

    this is just a very polite request.

    Thanks to allow me the part of your blog site.

  3. Respected Sir,
    i am also a small growing innovator in the field of diagnostic reagents.
    In todays arena such small peoples need proper guidance to groom and serve for the biotechnology industry & human life.
    I am very fond of research & found you sir equally very much fond of applying newer thoughts & ideas to explore the possiblity of seving the human life beyond books.
    "Strive for excellence, success will follow you."